Unique Genomic Arrangements in an Invasive Serotype M 23 strain of Streptococcus pyogenes 1

Unique Genomic Arrangements in an Invasive Serotype M23 strain of Streptococcus pyogenes 1 Identify Genes that Induce Hypervirulence 2 3 Yunjuan Bao, Zhong Liang, a* Claire Booyjzsen, Jeffrey A. Mayfield, Yang Li, Shaun W. 4 Lee, Victoria A. Ploplis, Hui Song, Francis J. Castellino 5 6 * Co-first authors, contributed equally to the work. 7 8 The W.M. Keck Center for Transgene Research and Department of Chemistry and 9 Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA, Tianjin Institute of 10 Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308 China, Department 11 of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. 12 13 Running title: emm23 GAS Genome 14 15